Square wave voltammetric quantification of folic acid, uric acid and ascorbic acid in biological matrix

Journal of Pharmaceutical Analysis

Masoud Giahi¹  Akram Pourhabib²  Majid Arvand³ 

[1] Department of Chemistry, Faculty of Science, Lahijan Branch, Islamic Azad University, P.O. Box: 1616, Lahijan, Iran;Education Organization of Guilan Province, Farhang Square, P.O. Box: 41849-83111, Rasht, Iran;Electroanalytical Chemistry Laboratory, Faculty of Science, University of Guilan, Namjoo Street, P.O. Box: 1914, Rasht, Iran;

关键词: Ascorbic acid;    Folic acid;    gold nanoparticles-modified carbon paste electrode;    Simultaneous determination;    Uric acid;   

DOI  :  10.1016/j.jpha.2017.01.002

来源: DOAJ

【 摘 要 】

Nowadays, modified electrodes with metal nanoparticles have appeared as an alternative for the electroanalysis of various compounds. In this study, gold nanoparticles (GNPs) were chosen as interesting metal nanoparticles for modifying of carbon paste electrode (CPE). GNPs and the gold nanoparticles-modified carbon paste electrode (GNPs/CPE) were characterized by UV–Vis spectroscopy, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). GNPs/CPE as a simple and sensitive electrode was used to study three important biological molecules: folic acid (FA), uric acid (UA) and ascorbic acid (AA). Square wave voltammetry (SWV) was used as an accurate technique for quantitative measurements. A good linear relation was observed between anodic peak current (ipa) and FA (5.2 × 10−6 – 2.5 × 10−5 M), UA (1.2 × 10−6 – 2.1 × 10−5 M) and AA (1.2 × 10−6 – 2.5 × 10−5 M) concentrations in simultaneous determination of these molecules.

【 授权许可】

Unknown