Effect of rhizomes of Curculigo orchioides on Thioacetamide induced hepatotoxicity

Environment Conservation Journal

SomeshThapliyal¹  AnilBhandari²  VijayJuyal³ 

[1] Department of Pharmaceutical Sciences HNB Garhwal (ACentral) University, Srinagar Garhwal Uttarakhnd, India.;Department of Pharmaceutical Sciences, Jodhpur National University, Jodhpur, Rajasthan, India.;Department of Pharmaceutical Sciences, Kumaun University, Bhimtaal, Uttarakhand, India.;

关键词: Amaryllidaceae;    Curculigo orchioides;    hepatoprotective;    silymarin;    thioacetamide;   

DOI  :  10.36953/ECJ.2014.151207

来源: DOAJ

【 摘 要 】

The hepatoprotective activity of methanolic rhizome extract of Curculigo orchioides (MECO) were evaluated against Thioacetamide-induced hepatic damage in rats. The MECO at dose of 100, 200 and 400 mg/kg were administered orally once daily for 21 days and simultaneously administered TAA 100 mg/kg b.w. s.c. 1 h after the respective assigned treatments every 72 h.  Serum enzymatic levels of serum glutamate oxaloacetate transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (ALP) and total bilirubin were estimated along with estimation of superoxide dismutase (SOD) and malondialdehyde (MDA) levels in liver tissues.

【 授权许可】

Unknown