Role of chondroitin sulfate in the regulation of neuroimmunoendocrine network interactions in patients with neurological symptoms in the post-covid period

Nevrologiâ, Nejropsihiatriâ, Psihosomatika

M. Yu. Maksimova¹  Yu. S. Prokofyeva²  O. A. Gromova³  I. V. Sarvilina⁴  M. N. Sharov⁵ 

[1] Big Data Storage and Analysis Center, National Center for Digital Economy, M.V. Lomonosov Moscow State University;A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia;Institute of pharmacoinformatics, Federal Research Center«Informatics and Management», Russian Academy of Sciences;Medical Centre «Novomeditsina»;Research Center of Neurology;

关键词: covid-19;    neurological symptoms;    neuroimmunoendocrine dysregulation;    chondroitin sulfate;   

DOI  :  10.14412/2074-2711-2021-6-105-110

来源: DOAJ

【 摘 要 】

The review discusses the prospects for the use of chondroitin sulfate and its derivatives for new indications in patients with and myalgic encephalomyelitis/chronic fatigue syndrome after SARS-CoV-2 infection. The epidemiology, clinical  manifestations, main mechanisms of the development of the dysregulation of neuroimmunoendocrine network interactions  in long-term COVID-19 are considered. Modern data on the relationship between mechanisms of neuroprotective effects of  chondroitin sulfate and its derivatives and their chemical  structure characteristics have been analyzed. The position is  argued according to which chondroitin sulfate and its  derivatives can become promising drugs in prevention of the  development of neuroimmunoendocrine network interactions  disorders in COVID-19.

【 授权许可】

Unknown