A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies

Cancers

Hiroaki Komuro¹  Masako Harada²  Shakhlo Aminova³  Alexis Forterre⁴ 

[1] Department of Cardiovascular Physiology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan;Institute for Quantitative Health Sciences and Engineering (IQ), Michigan State University, East Lansing, MI 48824, USA;Lyman Briggs College, Michigan State University, East Lansing, MI 48825, USA;UMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, 67200 Strasbourg, France;

关键词: microRNA delivery;    cancer therapy;    therapeutic RNA;    extracellular vesicles;   

DOI  :  10.3390/cancers12071852

来源: DOAJ

【 摘 要 】

In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating physiological processes and cancer pathogenesis have been a revolutionary discovery over the last decade. It is now considered that miRNA dysregulation influences critical molecular pathways involved in tumor progression, invasion, angiogenesis and metastasis in a wide range of cancer types. Hence, altering miRNA levels in cancer cells has promising potential as a therapeutic intervention, which is discussed in many other articles in this Special Issue. Some of the most significant hurdles in therapeutic miRNA usage are the stability and the delivery system. In this review, we cover a comprehensive update on the challenges and strategies for the development of therapeutic miRNA delivery systems that includes virus-based delivery, non-viral delivery (artificial lipid-based vesicles, polymer-based or chemical structures), and recently emerged extracellular vesicle (EV)-based delivery systems.

【 授权许可】

Unknown