Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver

Iranian Journal of Basic Medical Sciences

Sirous Rafiei Asl¹  maryam shirani²  atefeh Raesi Vanani²  Mohammad Amin Dehghani²  Masoud Mahdavinia²  Said Alizadeh²  Meysam Alipour³  Hedayat Allah Shahmohammadi³ 

[1] Department of Clinical Pathology, School of Veterinary Medicine, University of Shahid Chamran, Ahvaz, Iran;Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;

关键词: Bisphenol A;    Liver;    Mitochondria;    Oxidative stress;    Quercetin;    ROS;   

DOI  :  10.22038/ijbms.2019.32486.7952

来源: DOAJ

【 摘 要 】

Objective(s): Recognized as a distinguished environmental and global toxicant, Bisphenol A (BPA) affects the liver, which is a vital body organ, by the induction of oxidative stress. The present study was designed to investigate the protective effect of quercetin against BPA in hepatotoxicity in Wistar rats and also, the activity of mitochondrial enzymes were evaluated. Materials and Methods: To this end, 32 male Wistar rats were divided into four groups (six rats per group), including control, BPA (250 mg/kg), BPA + quercetin (75 mg/kg), and quercetin (75 mg/kg).Results: The BPA-induced alterations were restored in concentrations of alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) due to the quercetin treatment (75 mg/kg) (all P

【 授权许可】

Unknown