Primary leptomeningeal melanocytosis: A case report with an autopsy diagnosis

Vojnosanitetski Pregled

关键词: meningeal neoplasms;    diagnosis;    tomography, x-raycomputed;    magnetic resonance imaging;    autopsy;    6enzyme-linked immunosorbent assay;   

DOI  :  10.2298/VSP1207631Z

来源: DOAJ

【 摘 要 】

Introduction. Primary melanocytosis of the leptomeninges is a rare tumor,most likely originating from the melanocytes in the leptomeninges. Theaverage survival is only about 5 months. Case report. A 61- years-old womanpresented with headache, amaurosis and hallucinations lasted for two months,and she had been treated at the Clinic for Psychiatry and Clinic forInfectious Diseases. The cerebrospinal fluid analysis showed a lower level ofglucose and a higher level of proteins. Small shaded areas of basalleptomeninges and hydrocephalus were found by computed tomography andmagnetic resonance imaging. The autopsy showed a dark brown mass on basalleptomeninges with blurred boundaries. No pigmented skin lesions were found.Histopathological analysis revealed a primary leptomeningeal melanocytosis.Conclusion. Primary leptomeningeal melanocytosis is a rare tumor, difficultto diagnose. This case is being presented for its specificity, since thisdiagnosis is not frequently seen in practice.

【 授权许可】

Unknown