The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion

Nutrients

Sandro Giannini¹  Salvatore Minisola²  Nicola Napoli³  Luigi Sinigaglia⁴  Andrea Giusti⁵  Maurizio Rossini⁶  Giovanni Passeri⁷ 

[1] Clinica Medica 1, Department of Medicine, University of Padova, 35128 Padova, Italy;Department of Clinical, Internal, Anaesthesiology, and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy;Division of Endocrinology and Diabetes, Universita Campus Bio-Medico di Roma, 00128 Rome, Italy;Division of Rheumatology, ASST Gaetano Pini-CTO, 20122 Milano, Italy;Metabolic Bone Disease Unit & Fracture Liaison Service, Department of Medical Specialties, Regional Health Trust 3, 16125 Genova, Italy;Rheumatology Unit, Department of Medicine, University of Verona, 37134 Verona, Italy;Unit of Clinica e Terapia Medica, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy;

关键词: vitamin D;    immune-mediated disease;    cholecalciferol;    COVID-19;   

DOI  :  10.3390/nu14030473

来源: DOAJ

【 摘 要 】

Historically, vitamin D is recognized as an essential component for the maintenance of the musculoskeletal system. The immunomodulatory role of vitamin D in health and disease has gained much interest in recent years due to the many pathologies that share underlying immunological features where vitamin D has been shown to exert a potential role. Evidence from pre-clinical studies show that vitamin D elicits biological effects on both the innate and adaptive immune systems. Furthermore, in vivo studies have shown that administration of vitamin D can lead to changes in or the development of a range of immune-related diseases. This encourages the hypothesis that data derived from clinical and epidemiological studies connect vitamin D with the incidence and severity of many immune-mediated disorders such as rheumatoid arthritis, diabetes, and infectious diseases. Since some other immune-mediated diseases share similar features to that of viral infection such as COVID-19, in this review, we examined these other areas and the role of vitamin D in these diseases.

【 授权许可】

Unknown