Tau Seeding Mouse Models with Patient Brain-Derived Aggregates

International Journal of Molecular Sciences

Michael Schöll¹  Thomas Vogels¹  Aiko Robert¹ 

[1] Department of Neurodegenerative Disease, UCL Queen Square, Institute of Neurology, University College London, London WC1N 3BG, UK;

关键词: tau;    tauopathy;    Alzheimer’s disease;    animal model;    neurodegeneration;    seeding;   

DOI  :  10.3390/ijms22116132

来源: DOAJ

【 摘 要 】

Tauopathies are a heterogeneous class of neurodegenerative diseases characterized by intracellular inclusions of aggregated tau proteins. Tau aggregates in different tauopathies have distinct structural features and can be found in different cell types. Transgenic animal models overexpressing human tau have been used for over two decades in the research of tau pathology. However, these models poorly recapitulate the heterogeneity of tauopathies found in human brains. Recent findings demonstrate that injection of purified tau aggregates from the brains of human tauopathy patients recapitulates both the structural features and cell-type specificity of the tau pathology of the donor tauopathy. These models may therefore have unique translational value in the study of functional consequences of tau pathology, tau-based diagnostics, and tau targeting therapeutics. This review provides an update of the literature relating to seeding-based tauopathy and their potential applications.

【 授权许可】

Unknown