New Promising Therapeutic Avenues of Curcumin in Brain Diseases

Molecules

Melania Ruggiero¹  Maria Antonietta Panaro¹  Ilaria Pizzolorusso²  Dario Domenico Lofrumento³  Tarek Benameur⁴  Teresa Trotta⁵  Giovanni Messina⁵  Chiara Porro⁵  Vincenzo Monda⁵  Giulia Giacomucci⁶ 

[1] Biotechnologies and Biopharmaceutics, Department of Biosciences, University of Bari, 70125 Bari, Italy;Child and Adolescent Neuropsychiatry Unit, Department of Mental Health, ASL Foggia, 71121 Foggia, Italy;Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, 73100 Lecce, Italy;Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi Arabia;Department of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy;Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy;

关键词: curcumin;    natural flavonoid;    neuroinflammation;    anti-inflammatory;    neurodegenerative diseases;    Alzheimer’s diseases;   

DOI  :  10.3390/molecules27010236

来源: DOAJ

【 摘 要 】

Curcumin, the dietary polyphenol isolated from Curcuma longa (turmeric), is commonly used as an herb and spice worldwide. Because of its bio-pharmacological effects curcumin is also called “spice of life”, in fact it is recognized that curcumin possesses important proprieties such as anti-oxidant, anti-inflammatory, anti-microbial, antiproliferative, anti-tumoral, and anti-aging. Neurodegenerative diseases such as Alzheimer’s Diseases, Parkinson’s Diseases, and Multiple Sclerosis are a group of diseases characterized by a progressive loss of brain structure and function due to neuronal death; at present there is no effective treatment to cure these diseases. The protective effect of curcumin against some neurodegenerative diseases has been proven by in vivo and in vitro studies. The current review highlights the latest findings on the neuroprotective effects of curcumin, its bioavailability, its mechanism of action and its possible application for the prevention or treatment of neurodegenerative disorders.

【 授权许可】

Unknown