Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Frontiers in Bioengineering and Biotechnology

Junyao Cheng²  Zheng Wang³  Zhongyang Liu³  Bing Wu³  Peifu Tang³  Jianheng Liu³  Ming Li³  Xing Wang⁴ 

[1] Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China;Chinese PLA Medical School, Beijing, China;Department of Orthopaedics, Chinese PLA General Hospital, Beijing, China;University of Chinese Academy of Sciences, Beijing, China;

关键词: graphene;    bone tissue engineering;    scaffolds;    membranes;    coatings;   

DOI  :  10.3389/fbioe.2021.734688

来源: DOAJ

【 摘 要 】

Bone regeneration or replacement has been proved to be one of the most effective methods available for the treatment of bone defects caused by different musculoskeletal disorders. However, the great contradiction between the large demand for clinical therapies and the insufficiency and deficiency of natural bone grafts has led to an urgent need for the development of synthetic bone graft substitutes. Bone tissue engineering has shown great potential in the construction of desired bone grafts, despite the many challenges that remain to be faced before safe and reliable clinical applications can be achieved. Graphene, with outstanding physical, chemical and biological properties, is considered a highly promising material for ideal bone regeneration and has attracted broad attention. In this review, we provide an introduction to the properties of graphene and its derivatives. In addition, based on the analysis of bone regeneration processes, interesting findings of graphene-based materials in bone regenerative medicine are analyzed, with special emphasis on their applications as scaffolds, membranes, and coatings in bone tissue engineering. Finally, the advantages, challenges, and future prospects of their application in bone regenerative medicine are discussed.

【 授权许可】

Unknown