Recent applications of click chemistry for the functionalization of gold nanoparticles and their conversion to glyco-gold nanoparticles

Beilstein Journal of Organic Chemistry

Antony J. Fairbanks¹  Vladimir B. Golovko¹  Vivek Poonthiyil²  Thisbe K. Lindhorst² 

[1] Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, 8140, New Zealand;Otto Diels Institute of Organic Chemistry, Christiana Albertina University of Kiel, Otto-Hahn-Platz 3/4, Kiel, 24098, Germany;

关键词: azide–alkyne Huisgen cycloaddition;    carbohydrates;    click chemistry;    glyco-gold nanoparticles;    triazole;   

DOI  :  10.3762/bjoc.14.2

来源: DOAJ

【 摘 要 】

Glycoscience, despite its myriad of challenges, promises to unravel the causes of, potential new detection methods for, and novel therapeutic strategies against, many disease states. In the last two decades, glyco-gold nanoparticles have emerged as one of several potential new tools for glycoscientists. Glyco-gold nanoparticles consist of the unique structural combination of a gold nanoparticle core and an outer-shell comprising multivalent presentation of carbohydrates. The combination of the distinctive physicochemical properties of the gold core and the biological function/activity of the carbohydrates makes glyco-gold nanoparticles a valuable tool in glycoscience. In this review we present recent advances made in the use of one type of click chemistry, namely the azide–alkyne Huisgen cycloaddition, for the functionalization of gold nanoparticles and their conversion to glyco-gold nanoparticles.

【 授权许可】

Unknown