Emerging threat of drug-resistant tuberculosis and trends in the era of COVID-19: A descriptive study from northwestern Nigeria

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

Garba Iliyasu¹  Bashir Garba Ahmad²  Ibrahim Aliyu Umar³  Mamman Bajehson⁴  Oji Akpala⁵  Abdulrazaq Garba Habib⁶  Farouq Muhammad Dayyab⁶  Olaoye Remilekun⁶  Ibrahim Muhammad Daiyab⁷  Nura Musa Shuaib⁸ 

[1] Corresponding author at: Infectious Diseases Hospital, Kano, Zone 1 Municipal, No 1 Weather Head, Kano Nigeria.;Department of Medicine, College of Health Sciences, Bayero University, Kano, Nigeria;Department of Medicine, Muhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria;Field Presence Cluster, World Health Organization, Kano State, Nigeria;Health Development Alternative Initiative, Kano, Nigeria;Infectious Disease Hospital, Kano, Nigeria;KNCV Tuberculosis Foundation, Kano Cluster Office, Kano, Nigeria;Tuberculosis, Leprosy and Buruli Ulcer Control Program, Public Health and Disease Control Department, Ministry of Health, Kano, Nigeria;

关键词: Drug-resistant TB;    Tuberculosis;    COVID-19;    Nigeria;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Mycobacterium tuberculosis with resistance to first line and second line anti tuberculous drugs is a serious setback in the treatment of tuberculosis (TB). The COVID-19 pandemic constitutes a serious threat that could unwind the recent gains made thus far in the control of tuberculosis. This study aims to explore the pattern of drug resistant tuberculosis (DRTB) in our institution. We also aimed to explore the changing trends of TB in the era of the COVID-19 pandemic. Methods: This descriptive study included all DRTB patients admitted and managed in the hospital between January 2018 and December 2020. We compare TB case detection in the facility before and after COVID-19 pandemic. Drug susceptibility testing were expressed as frequencies and percentages. Results: The study found that there was 66.03%, 45.09% and 77.78% drop in case detection of drug-sensitive TB (DSTB), DRTB and Fluoroquinolone (FQ) resistant TB respectively in the year 2020 compared to 2019. The drop in cases was similar when the year 2020 was compared to 2018. Among the 132 patients in the cohort, resistance to isoniazid, fluoroquinolones and second-line injectable agents were reported as 23.48%, 12.88%, and 31.06% respectively. Conclusion: We question the potential reason why a drop in tuberculosis cases was observed in the year 2020 and we alert the Nigerian authorities that COVID-19 control efforts going hand-in-hand with intensified TB case finding and surveillance efforts and initiating proper TB treatment for persons with active TB are urgently needed.

【 授权许可】

Unknown