Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma

Cancer Medicine

Allan Tsung¹  Zachary J. Brown¹  Yujia Xia¹  Hai Huang¹ 

[1] Division of Surgical Oncology Department of Surgery The Ohio State University Wexner Medical Center Columbus OH USA;

关键词: hepatocellular carcinoma;    immune cells;    metabolic reprogramming;    tumor immunology;    tumor microenvironment;   

DOI  :  10.1002/cam4.4177

来源: DOAJ

【 摘 要 】

Abstract Hepatocellular carcinoma (HCC) is a typical inflammation‐induced cancer and displays a complex interaction between the tumor microenvironment and tumor development. Immune cells in the HCC microenvironment play both pro‐ and anti‐tumoral roles in HCC progression. An increasing number of findings indicate that metabolic reprogramming is essential for immune cell differentiation and function. In this review, we discuss the metabolic changes of different immune cells and correlate these findings to HCC progression.

【 授权许可】

Unknown