期刊论文详细信息
American Journal of Ophthalmology Case Reports
Role of intravitreal brolucizumab with intravitreal rtPA and pneumatic displacement for submacular hemorrhage: A case series
Jay U. Sheth1  Subhendu Boral2  Debdulal Chakraborty2  Soumen Mondal3 
[1] Corresponding author. Disha Eye Hospitals, 88 Ghosh para Road, Barrackpore, Kolkata, 700120, India.;Department of Vitreoretinal Services, Disha Eye Hospitals Kolkata, India;Department of Vitreoretinal Services, Surya Eye Institute and Research Center, Mumbai, India;
关键词: Brolucizumab;    Submacular hemorrhage;    Anti-vascular endothelial growth factor;   
DOI  :  
来源: DOAJ
【 摘 要 】

Purpose: To evaluate the role of intravitreal injection (IVI) of brolucizumab along with intravitreal recombinant tissue plasminogen activator (rtPA) and C3F8 gas injection for large submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (nAMD). Observations: This was a prospective uncontrolled non-randomized case series conducted at a single site. Three patients with fresh SMH (≤4 days) secondary to nAMD underwent triple therapy with IVI brolucizumab + intravitreal rtPA (50 μg in 0.1 mL) + 0.3 mL of 100% C3F8 gas injection. Post-injection, a face-down position was advised for 5 days with periodic follow-up visits. All three patients had complete resolution of SMH at the end of 4 weeks with a notable improvement in the best-corrected visual acuity (BCVA). No optical coherence tomographic (OCT) biomarkers of disease activity were noted at the end of 12 weeks in the first and the third case and 4 weeks in the second case respectively. There were no ocular or systemic side effects reported in any of the cases. Conclusions and importance: Intravitreal brolucizumab administered along with intravitreal rtPA and C3F8 gas injection was found to be efficacious and safe for the management of large SMH secondary to nAMD. Complete displacement of SMH with excellent structural and functional outcomes can be seen with triple therapy.

【 授权许可】

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