THE PERSPECTIVES OF DEVELOPMENT OF NEW PEPTIDE PREPARATIONS FOR CLINICAL USE WHICH HAVE ANTI-INFECTION AND IMMUNE-MODULATING ACTIVITY

Infekciâ i Immunitet

L. A. Andreeva¹  I. Ju. Nagaev¹  N. F. Miasoedov¹  A. N. Narovlianskiy²  V. E. Scherbenko²  M. V. Mezentseva²  L. I. Russu²  I. M. Shapoval² 

[1] Институт молекулярной генетики РАН, Москва;ФГБУ НИИЭМ им. Н.Ф. Гамалеи Минздравсоцразвития России, Москва;

关键词: peptides;    glycoprolines;    selank;    cytokines;    pharmacophor;   

DOI  :  10.15789/2220-7619-2011-2-171-176

来源: DOAJ

【 摘 要 】

Abstract. The aim of current work is to study influence of peptides in vitro and in vivo on cytokines synthesis (IFNα, IFNγ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, TNFα) on the level of their transcription and production. The study of synthesized peptides has shown that all of them had antiviral activity related to tested pathogens (HSV, influenza H3N2, VEMC) with different grade. It could be explained by induction of cytokine response under the action of peptides in norm and in case of viral infections in vitro. However, data obtained in vivo, more adequately characterized antiviral activity of synthesized peptides. The results of study have shown that minimal fragments which had antiviral characteristics are dual peptides Thr-Lys and Gly-Pro; more active as antiviral was peptide Gly-Pro. Thus, our conception about possibility of minimal fragment’s selection from Selank peptide sequence having antiviral activity has been confirmed. This make possible directional construction of new peptides for clinical use which will be helpful in combating with social related diseases as influenza, herpes viral infection etc.

【 授权许可】

Unknown