Metabolomics-Based Frailty Biomarkers in Older Chinese Adults

Frontiers in Medicine

Zuyun Liu¹  Pan Liu²  Yaxin Zhang²  Lina Ma²  Yun Li²  Yiming Pan²  Bowen Li³  Guanghou Shui⁴ 

[1] Center for Clinical Big Data and Analytics, School of Public Health, Second Affiliated Hospital and Department of Big Data in Health Science, Zhejiang University School of Medicine, Hangzhou, China;Department of Geriatrics, National Research Center for Geriatric Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China;LipidALL Technologies Company Limited, Changzhou, China;State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China;

关键词: frailty;    metabolomics;    physical function;    biomarker;    older adults;   

DOI  :  10.3389/fmed.2021.830723

来源: DOAJ

【 摘 要 】

Background/ObjectivesOwing to accelerated population aging, health in older adults is becoming increasingly important. Frailty can reflect the health status and disease risks of older adults; however, appropriate biomarkers for early screening of frailty have not been identified. Here, we applied metabolomics to identify frailty biomarkers and potential pathogenic mechanisms of frailty.MethodsSerum metabolic profiles from 25 frail and 49 non-frail (control) older adults were systematically investigated by liquid chromatography-mass spectrometry-based metabolomics.ResultsWe identified 349 metabolites of 46 classes, with four increased and seven decreased metabolites in frail older adults. Pearson correlation analysis identified 11 and 21 metabolites that were positively and negatively correlated with grip strength, and 7 and 76 metabolites that were positively and negatively correlated with gait speed, respectively. Pathway analysis identified 10 metabolite sets and 13 pathways significantly associated with one or more frailty phenotype criteria.ConclusionThese results revealed the metabolite characteristics of serum in frail older adults. Intermediates of carbohydrate metabolism (e.g., isocitrate, malate, fumarate, cis-aconitate, glucuronate, and pyruvate), saturated fatty acids (e.g., palmitic acid), unsaturated fatty acids (e.g., arachidonate and linoleic acid), and certain essential amino acids (e.g., tryptophan) may be candidate biomarkers for the early diagnosis of frailty. Mitochondrial function disorders, saturated fatty acid-mediated lipotoxicity, aberrant unsaturated fatty acid metabolism, and increased tryptophan degradation could be potential mechanisms of frailty.

【 授权许可】

Unknown