Vonoprazan versus lansoprazole in the treatment of artificial gastric ulcers after endoscopic submucossal dissection: a randomized, open-label trial

BMC Gastroenterology

Ryuta Takenaka¹  Koji Takemoto¹  Hirofumi Tsugeno¹  Shigeatsu Fujiki¹  Mikako Ishiguro¹  Tatsuhiro Gotoda¹  Yoshiyasu Kono¹  Daisuke Kawai¹  Shotaro Okanoue¹ 

[1]Department of Gastroenterology, Tsuyama Chuo Hospital

关键词: Vonoprazan;    Lansoprazole;    Postoperative bleeding;    Endoscopic submucosal dissection;    Gastric neoplasm;   

DOI  :  10.1186/s12876-021-01822-5

来源: DOAJ

【 摘 要 】

Abstract Background Vonoprazan is more potent and longer acting than traditional proton pump inhibitor. Although vonoprazan is expected to be superior to proton pump inhibitor, its efficacy in the treatment of gastric ulcers following endoscopic submucosal dissection (ESD) is not fully understood. The aim of this study was to evaluate the effectiveness of vonoprazan in artificial ulcer healing following ESD. Methods Patients with gastric tumors were randomly assigned to the vonoprazan group (group V) or lansoprazole group (group L) after ESD. Patients received intravenous lansoprazole (30 mg) twice on the day of ESD. Thereafter, patients were treated with vonoprazan (20 mg/day) in group V or lansoprazole (30 mg/day) in group L. Esophagogastroduodenoscopy was performed 4 and 8 weeks after the ESD. Results A total of 168 patients were analyzed. The 4-week healing rate for artificial ulcer was not significantly higher in group V versus group L (17/85, 20.0% vs. 14/83, 16.9%, respectively). In addition, there were no significant differences between the 4-week shrinkage rates between the two groups. Postoperative bleeding occurred in none of the patients in group V and three in group L. One patient in group V presented delayed perforation 2 days after ESD. Conclusions Vonoprazan might not be superior to lansoprazole in the healing of artificial gastric ulcer after ESD. Trial registration: University hospital Medical Information Network (registration number: UMIN000016642), Registered 27 February 2015, https://www.umin.ac.jp/ctr/index-j.htm.

【 授权许可】

Unknown