Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors

Neoplasia: An International Journal for Oncology Research

关键词: Warburg effect;    hypoxia-inducible factor;    glucose consumption;    lactate;    glycolysis;   

DOI  :  10.1593/neo.04430

来源: DOAJ

【 摘 要 】

Metastatic tumors generally exhibit aerobic glycolysis (the Warburg effect). The advent of [18F]fluorodeoxyglucose positron emission tomography imaging, coupled with recent findings linking hypoxia-inducible factor (HIF-1α) overexpression to aggressive cancers, has rekindled an interest in this aspect of tumor metabolism. These studies explore the role of HIF-1α in human breast cancer lines and its relationship to glycolytic regulation. Here we demonstrate that, under normal oxygen conditions, nonmetastatic cells consume less glucose and express low HIF-1α, whereas metastatic cells constitutively express high glycolysis and HIF-1α, suggesting that dysregulation of HIF-1α may induce the Warburg effect. This hypothesis was tested by renormalizing HIF-1α levels in renal carcinoma cells, leading to inhibition of aerobic glycolysis.

【 授权许可】

Unknown