Crosstalk of Epigenetic and Metabolic Signaling Underpinning Glioblastoma Pathogenesis

Cancers

Athanasios G. Papavassiliou¹  Kostas A. Papavassiliou¹  Dimitrios Strepkos¹  Christina Piperi¹  Mariam Markouli¹ 

[1] Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece;

关键词: glioma;    glioblastoma;    methylation;    acetylation;    histones;    DNA;   

DOI  :  10.3390/cancers14112655

来源: DOAJ

【 摘 要 】

Metabolic alterations in neoplastic cells have recently gained increasing attention as a main topic of research, playing a crucial regulatory role in the development and progression of tumors. The interplay between epigenetic modifications and metabolic pathways in glioblastoma cells has emerged as a key pathogenic area with great potential for targeted therapy. Epigenetic mechanisms have been demonstrated to affect main metabolic pathways, such as glycolysis, pentose phosphate pathway, gluconeogenesis, oxidative phosphorylation, TCA cycle, lipid, and glutamine metabolism by modifying key regulatory genes. Although epigenetic modifications can primarily promote the activity of metabolic pathways, they may also exert an inhibitory role. In this way, they participate in a complex network of interactions that regulate the metabolic behavior of malignant cells, increasing their heterogeneity and plasticity. Herein, we discuss the main epigenetic mechanisms that regulate the metabolic pathways in glioblastoma cells and highlight their targeting potential against tumor progression.

【 授权许可】

Unknown