The Multifaceted Effects of Gut Microbiota on the Immune System of the Intestinal Mucosa

Immuno

Hiroshi Nakase¹  Takehiro Hirano¹ 

[1] Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Minami 1-jo Nishi 16-chome, Chuo-ku, Sapporo 060-8543, Japan;

关键词: gut microbiota;    mucosal immunity;    metabolites;    inflammatory bowel disease;    colon carcinogenesis;    COVID-19;   

DOI  :  10.3390/immuno1040041

来源: DOAJ

【 摘 要 】

The gut microbiota has diverse microbial components, including bacteria, viruses, and fungi. The interaction between gut microbiome components and immune responses has been studied extensively over the last decade. Several studies have reported the potential role of the gut microbiome in maintaining gut homeostasis and the development of disease. The commensal microbiome can preserve the integrity of the mucosal barrier by acting on the host immune system. Contrastingly, dysbiosis-induced inflammation can lead to the initiation and progression of several diseases through inflammatory processes and oxidative stress. In this review, we describe the multifaceted effects of the gut microbiota on several diseases from the perspective of mucosal immunological responses.

【 授权许可】

Unknown