Urological Melanoma: A Comprehensive Review of a Rare Subclass of Mucosal Melanoma with Emphasis on Differential Diagnosis and Therapeutic Approaches

Cancers

Caterina Foti¹  Paolo Romita¹  Domenico Bonamonte¹  Angela Filoni¹  Gennaro Cormio²  Francesca Arezzo²  Vera Loizzi²  Alessandra Stellacci³  Maricla Marrone³  Pragnell Mary Victoria Candance⁴  Antonietta Cimmino⁴  Gabriella Serio⁴  Concetta Caporusso⁴  Andrea Marzullo⁴  Giuseppe Ingravallo⁴  Anna Colagrande⁴  Senia Maria Rosaria Trabucco⁴  Teresa Lettini⁴  Gerardo Cazzato⁴  Leonardo Resta⁴  Roberta Rossi⁴  Alfonso Lorusso⁵  Marcello Zingarelli⁵ 

[1] Section of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy;Section of Ginecology and Obstetrics, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy;Section of Legal Medicine, Interdisciplinary Department of Medicine, Bari Policlinico Hospital, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy;Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy;Section of Urology, Deparment of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, Italy;

关键词: melanoma;    mucosal melanoma;    urology;   

DOI  :  10.3390/cancers13174424

来源: DOAJ

【 摘 要 】

Melanoma is reported as the 19th most common cancer worldwide, with estimated age-standardized incidence rates of 2.8–3.1 per 100,000. Although the origin is most frequently cutaneous, mucosal melanoma has been described several times in literature, and despite its rarity (only 1% of all melanomas), increasing attention is being paid to this disease form. Within this subgroup, melanomas of the uropoetic apparatus are a rarity among rarities. Indeed, less than 50 cases of primary melanoma originating from the urinary bladder have been described, and even less originating from the kidney, renal pelvis and urethra. In this work, we present a detailed review of the literature related to this subclass of mucosal melanoma, delve into the biological landscape of this neoplasm and discuss current approaches, future perspectives and potential therapeutic approaches.

【 授权许可】

Unknown