IMPACT OF ANTIEPILEPTIC DRUGS ON COGNITIVE FUNCTIONS: FOCUS ON PERAMPANEL

Эпилепсия и пароксизмальные состояния

E. D. Belousova¹ 

[1] The Russian National ResearchMedical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation;

关键词: epilepsy;    children;    adolescents;    cognitive adverse effects;    antiepileptic drugs;    perampanel;   

DOI  :  10.17749/2077-8333.2016.8.3.006-010

来源: DOAJ

【 摘 要 】

Cognitive problems in epilepsy have a multifactorial origin with etiology, seizures, and the «central» side-effects of drug treatment being involved. Cognitive side effects  of antiepileptic drugs (AEDs) have been demonstrated to be one of the most important tolerability problems in chronic AED treatment, especially in children with epilepsy. Memory impairments, mental slowing, and attentional deficits are the most frequently reported ones. Neuropsychological profiles of AEDs are important considerations  for treatment selection, particularly in children and adolescents.  In evaluating studies  of the cognitive effects  of AEDs we must  follow an evidence-based approach, but in the majority of cases,  specific data on cognitive functions  in children and adolescents  with epilepsy are not yet available. A randomized double blind trial on cognitive effects of adjunctive perampanel for partial-onset seizures is cited (Meador K. F. et al, 2015) and discussed. In this trial adjunctive perampanel did not have any significant overall negative cognitive effect and was improving episodic memory in adolescent patients with inadequately controlled partial-onset seizures.

【 授权许可】

Unknown