The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections

Pharmaceuticals

Ramin Goudarzi¹  Alireza Partoazar²  Shima Afrasiabi³  Nasim Chiniforush³ 

[1] Division of Research and Development, Pharmin USA, LLC, San Jose, CA 95128, USA;Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran 1441987566, Iran;Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran 1441987566, Iran;

关键词: photosensitizing agents;    photochemotherapy;    dental infection control;    drug resistance;    biofilms;    nanoparticles;   

DOI  :  10.3390/ph15060767

来源: DOAJ

【 摘 要 】

Oral health problems and the emergence of antimicrobial resistance among pathogenic bacterial strains have become major global challenges and are essential elements that negatively affect general well-being. Antimicrobial photodynamic therapy (APDT) is based on a light source and oxygen that activates a nontoxic photosensitizer, resulting in microbial destruction. Synthetic and natural products can be used to help the APDT against oral microorganisms. The undesirable consequences of conventional photosensitizers, including toxicity, and cost encourage researchers to explore new promising photosensitizers based on natural compounds such as curcumin, chlorella, chlorophyllin, phycocyanin, 5-aminolevulinic acid, and riboflavin. In this review, we summarize in vitro studies describing the potential use of APDT therapy conjugated with some natural products against selected microorganisms that are considered to be responsible for oral infections.

【 授权许可】

Unknown