Intractable hyperkalemia due to nicorandil induced potassium channel syndrome

Annals of Cardiac Anaesthesia

关键词: Atrial fibrillation;    Cardiac surgery;    Diastolic dysfunction;    Diastolic function;    Postoperative;    Postoperative pain;    presternal bupivacaine infusion;    sternotomy;    Aprotinin;    Bleeding;    Cardiopulmonary bypass;    Paediatric open-heart surgery;    Tranexamic acid;    Airway;    dexmedetomidine;    radiographic assessment;    Cardiac resynchronization therapy;    coronary artery bypass;    heart failure;    Acute kidney injury;    Cardiac surgery;    Neutrophil gelatinase-associated lipocalin;    Anti-platelet therapy;    Bleeding;    Coronary artery bypass grafting;    Multiplate;    Platelet Dysfunction;    Platelet function assessment;    Developing country;    outcomes;    quality improvement;    Cardiac surgery;    Davinci;    One-lung ventilation;    Totally endoscopic coronary artery bypass;    Transesophageal echocardiography;    Robotic surgery;    Minimally invasive cardiac surgery;    Atrial septal defects;    Congenital heart disease;    Echocardiography;    Transthoracic echocardiography;    Transesophageal echocardiography;    Three- dimensional echocardiography;    Two-dimensional echocardiography;    Clinical research;    measurement types;    predictive modelling;    statistical analysis;    Aortic dissection flap;    intra-operative echocardiography;    three-dimensional transesophageal echocardiography;    type A aortic dissection;    Left ventricular rupture;    mitral valve replacement;    risk factors;    Coronary artery bypass graft;    hypoxemia;    patent foramen ovale;    stroke;    Left ventricle;    Myxoma;    Thrombus;    Anesthesia;    Aortic stenosis;    Aortic valve replacement;    Cesarean section;    Pregnancy;    ATP-sensitive potassium channels;    channelopathy;    hyperkalemia;    nicorandil;   

DOI  :  10.4103/0971-9784.148331

来源: DOAJ

【 摘 要 】

Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of K ATP channel, it can expel K + ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy.

【 授权许可】

Unknown