A Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity

Frontiers in Pharmacology

Nian Liu¹  Linling Li¹  Le Jiang¹  Yong Tang²  Hebin Tang³  Yanwei Xing⁴  Xinyu Yang⁵  Xinye Li⁵  Yonghong Gao⁵  Xiaofeng Wang⁵  Yihan Yang⁵  Hongcai Shang⁵ 

[1] Department of Cardiology, Beijing Anzhen Hospital of the Capital University of Medical Sciences, Beijing, China;Department of Pancreatic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China;Department of Pharmacology, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China;Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China;Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China;

关键词: anthracyclines;    traditional Chinese medicine;    cardiac toxicity;    adverse effects;    antineoplastic;   

DOI  :  10.3389/fphar.2018.00444

来源: DOAJ

【 摘 要 】

Anthracyclines are effective agents generally used to treat solid-tumor and hematologic malignancies. The use of anthracyclines for over 40 years has improved cancer survival statistics. Nevertheless, the clinical utility of anthracyclines is limited by its dose-dependent cardiotoxicity that adversely affects 10–30% of patients. Anthracycline-induced cardiotoxicity may be classified as acute/subacute or chronic/late toxicity and leads to devastating adverse effects resulting in poor quality of life, morbidity, and premature mortality. Traditional Chinese medicine has a history of over 2,000 years, involving both unique theories and substantial experience. Several studies have investigated the potential of natural products to decrease the cardiotoxic effects of chemotherapeutic agents on healthy cells, without negatively affecting their antineoplastic activity. This article discusses the mechanism of anthracycline-induced cardiotoxicity, and summarizes traditional Chinese medicine treatment for anthracycline-induced heart failure (HF), cardiac arrhythmia, cardiomyopathy, and myocardial ischemia in recent years, in order to provide a reference for the clinical prevention and treatment of cardiac toxicity.

【 授权许可】

Unknown