Pathogenetic features of endothelial dysfunction at respiratory-cardiac comorbidity

Кубанский научный медицинский вестник

O. S. Polunina¹  A. Kh. Akhmineeva¹  L. P. Voronina¹  I. V. Sevostyanova¹ 

[1] ГБОУ ВПО «Астраханская государственная медицинская академия» Минздрава России;

关键词: хроническая обструктивная болезнь легких;    бронхиальная астма;    ишемическая болезнь сердца;    артериальная гипертензия;    эндотелиальная дисфункция;    системное воспаление;    chronic obstructive pulmonary disease;    bronchial asthma;    coronary heart disease;    arterial hypertension;    endothelial dysfunction;    systemic inflammation;   

DOI  :  10.25207/1608-6228-2014-4-11-15

来源: DOAJ

【 摘 要 】

A correlation analysis to identify the relationship between markers of endothelial dysfunction (coefficient of endothelial function - EFC, type C natriuretic peptide, endothelin-1) and indicators reflecting the activity of inflammation (C - reactive protein, fractalkine) in patients with chronic obstructive pulmonary disease (COPD), bronchial asthma (BA), coronary heart disease (CHD), arterial hypertension (AH) and in patients with comorbidity (COPD+CHD, COPD+AH, BA+ CHD, BA+AH). It was revealed that at comorbid combinations COPD+AG, BA+AG basic mechanism of development of endothelial dysfunction is the activation of chemotactic inflammatory cascade with hyperproduction of fractalkine. C-reactive protein, fractalkine are diagnostic and prognostic markers defeat of endothelium in patients with combinations of COPD+ CHD, BA+CHD.

【 授权许可】

Unknown