Gender Difference in the Relationships between Inflammatory Markers, Serum Uric Acid and Framingham Risk Score

International Journal of Environmental Research and Public Health

Jui-Hua Huang¹  Feng-Cheng Tang²  Ren-Hau Li³  Shu-Ling Huang³  Chao-Hung Yu⁴  Hon-Ke Sia⁵ 

[1] Department of Golden-Ager Industry Management, Chaoyang University of Technology, Taichung 413, Taiwan;Department of Leisure Services Management, Chaoyang University of Technology, Taichung 413, Taiwan;Department of Psychology, Chung Shan Medical University, Taichung 402, Taiwan;Division of Cardiovascular Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan;Division of Endocrinology and Metabolism, Changhua Christian Hospital, Changhua 500, Taiwan;

关键词: Framingham Risk Score;    high-sensitivity C-reactive protein;    white blood cell;    serum uric acid;    cardiovascular disease;    gender;   

DOI  :  10.3390/ijerph18137103

来源: DOAJ

【 摘 要 】

The purpose of the present study was to explore the role of gender in the relation of high-sensitivity C-reactive protein (hsCRP), white blood cell (WBC) count, and serum uric acid (UA) to the risk of future cardiovascular disease (CVD) events. In total, 404 workers were recruited to obtain the measurements of serum markers for CVD risk. Demographic data, nutrition, exercise, smoking, and alcohol consumption were assessed through a questionnaire. The Framingham Risk Score (FRS) was adopted to estimate the risk of future CVD events. Multiple linear regression models were used to determine CVD risk markers in relation to the FRS by gender. The hsCRP was not significantly correlated with the FRS for all workers after adjusting for covariates, including demographic data and health-related lifestyle. WBC count was positively correlated with FRS for all workers, but WBC count did not show an interaction with gender with respect to the FRS. Serum UA showed an interaction with gender on the FRS, and UA positively correlated with the FRS in males though not in females. With respect to CVD prevention, the WBC count can be used to monitor the risk for all workers. Due to a gender difference shown in the relationship between serum UA and the FRS, serum UA can be a monitor of the risk of future CVD events in male workers only.

【 授权许可】

Unknown