Seamless integration of bioelectronic interface in an animal model via in vivo polymerization of conjugated oligomers

Bioactive Materials

Magnus Berggren¹  Angela Tino²  Roger Olsson³  David Bliman³  Federica Fardella⁴  Claudia Tortiglione⁴  Giuseppina Tommasini⁴  Eugenio Fergola⁴  Eleni Stavrinidou⁵  Gwennaël Dufil⁵  Tobias Abrahamsson⁵  Xenofon Strakosas⁵ 

[1] Chemical Biology &Therapeutics, Department of Experimental Medical Science, Lund University, SE-221 84, Lund, Sweden;Department of Chemistry and Molecular Biology, University of Gothenburg, SE-405 30, Gothenburg, Sweden;Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Italy;Laboratory of Organic Electronics, Department of Science and Technology, Linkoping University, SE-60174, Norrkoping, Sweden;

关键词: In vivo polymerization;    Bioelectronics interfaces;    Conjugated oligomers;    Model organism;   

DOI  :  

来源: DOAJ

【 摘 要 】

Leveraging the biocatalytic machinery of living organisms for fabricating functional bioelectronic interfaces, in vivo, defines a new class of micro-biohybrids enabling the seamless integration of technology with living biological systems. Previously, we have demonstrated the in vivo polymerization of conjugated oligomers forming conductors within the structures of plants.Here, we expand this concept by reporting that Hydra, an invertebrate animal, polymerizes the conjugated oligomer ETE-S both within cells that expresses peroxidase activity and within the adhesive material that is secreted to promote underwater surface adhesion. The resulting conjugated polymer forms electronically conducting and electrochemically active μm-sized domains, which are inter-connected resulting in percolative conduction pathways extending beyond 100 μm, that are fully integrated within the Hydra tissue and the secreted mucus. Furthermore, the introduction and in vivo polymerization of ETE-S can be used as a biochemical marker to follow the dynamics of Hydra budding (reproduction) and regeneration. This work paves the way for well-defined self-organized electronics in animal tissue to modulate biological functions and in vivo biofabrication of hybrid functional materials and devices.

【 授权许可】

Unknown