Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus

Molecules

Hao-Chieh Chiu¹  Chang-Shi Chen²  Chung-Wai Shiau³  Jung-Chen Su³  Yu-Ting Huang³ 

[1] Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei 10617, Taiwan;Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan;Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei 11221, Taiwan;

关键词: malonamide;    Staphylococcus aureus;    antibiotics;   

DOI  :  10.3390/molecules23010027

来源: DOAJ

【 摘 要 】

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.

【 授权许可】

Unknown