期刊论文详细信息
Research Integrity and Peer Review
A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)
on behalf of the IICARus Collaboration1  Kaitlyn Hair2  Malcolm R. Macleod2  Emily S. Sena2 
[1] ;Centre for Clinical Brain Sciences, University of Edinburgh;
关键词: ARRIVE;    Reporting guidelines;    Randomised controlled trial;   
DOI  :  10.1186/s41073-019-0069-3
来源: DOAJ
【 摘 要 】

Abstract Background The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines. Methods In a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems. Results We randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X 2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively. Conclusions These results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting.

【 授权许可】

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