Serotonin in Animal Cognition and Behavior

International Journal of Molecular Sciences

Rahul Bharatiya¹  Nouhaila Bouguiyoud¹  Julien Bacqué-Cazenave¹  Daniel Cattaert¹  Philippe De Deurwaerdère¹  Grégory Barrière¹  Jean-Paul Delbecque¹  Giuseppe Di Giovanni² 

[1] INCIA, UMR5287, Centre National de la Recherche Scientifique, 33076 Bordeaux, France;Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta;

关键词: serotonin receptor;    animal phyla;    mood;    decision-making;    locomotion;    anxiety;    neuronal excitability;    feeding;    aggressiveness;    impulsive/compulsive dimension;   

DOI  :  10.3390/ijms21051649

来源: DOAJ

【 摘 要 】

Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates. It has been proposed for several decades that it impacts animal cognition and behavior. In spite of a completely distinct organization of the 5-HT systems across the animal kingdom, several lines of evidence suggest that the influences of 5-HT on behavior and cognition are evolutionary conserved. In this review, we have selected some behaviors classically evoked when addressing the roles of 5-HT on nervous system functions. In particular, we focus on the motor activity, arousal, sleep and circadian rhythm, feeding, social interactions and aggressiveness, anxiety, mood, learning and memory, or impulsive/compulsive dimension and behavioral flexibility. The roles of 5-HT, illustrated in both invertebrates and vertebrates, show that it is more able to potentiate or mitigate the neuronal responses necessary for the fine-tuning of most behaviors, rather than to trigger or halt a specific behavior. 5-HT is, therefore, the prototypical neuromodulator fundamentally involved in the adaptation of all organisms across the animal kingdom.

【 授权许可】

Unknown