Players in Mitochondrial Dynamics and Female Reproduction

Frontiers in Molecular Biosciences

Dongmei Ji²  Zhiguo Zhang²  Li Yang³  Yunxia Cao⁴  Weiwei Zou⁴ 

[1] Anhui Province Key Laboratory of Reproductive Health and Genetics, Hefei, China;Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, China;Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China;Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Hefei, China;NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, China;Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China;

关键词: mitochondrial dynamics;    protein;    diseases;    therapy;    reproduction;   

DOI  :  10.3389/fmolb.2021.717328

来源: DOAJ

【 摘 要 】

Mitochondrial dynamics (fission and fusion) are essential physiological processes for mitochondrial metabolic function, mitochondrial redistribution, and mitochondrial quality control. Various proteins are involved in regulating mitochondrial dynamics. Aberrant expression of these proteins interferes with mitochondrial dynamics and induces a range of diseases. Multiple therapeutic approaches have been developed to treat the related diseases in recent years, but their curative effects are limited. Meanwhile, the role of mitochondrial dynamics in female reproductive function has attracted progressively more attention, including oocyte development and maturation, fertilization, and embryonic development. Here, we reviewed the significance of mitochondrial dynamics, proteins involved in mitochondrial dynamics, and disorders resulting from primary mitochondrial dynamic dysfunction. We summarized the latest therapeutic approaches of hereditary mitochondrial fusion–fission abnormalities and reviewed the recent advances in female reproductive mitochondrial dynamics.

【 授权许可】

Unknown