Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis

BMC Chemistry

Xinchi Feng¹  Kai Wang¹  Feng Qiu¹  Shijie Cao¹  Di Liu¹  Shuxiang Wei¹  Liqin Ding¹  Nan Zhang¹ 

[1] School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine;

关键词: Aesculus chinensis Bge. var. chekiangensis (Hu et Fang) Fang;    Phenylethanol glycosides;    Neuroprotective activity;   

DOI  :  10.1186/s13065-020-00685-3

来源: DOAJ

【 摘 要 】

Abstract Three new phenylethanol glycosides (1-3) and one known analogue (4) were isolated from the seeds of Aesculus chinensis Bge. var. chekiangensis. To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of Aesculus, which enriched its chemical composition. Structure elucidations were performed via extensive NMR and HRESIMS data together with comparison with literature data. Thereafter, the isolated compounds were assayed for their neuroprotective activities against CoCl2-induced cytotoxicity in PC12 cells and compound 3 exhibited moderate activity.

【 授权许可】

Unknown