D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats

Nutrients

Elena Baixeras¹  Alfonso Gutierrez-Adan²  Carlos Sanjuan³  FernandoRodríguez de Fonseca⁴  Margarita Vida⁴  Dina Medina-Vera⁴  JuanA. Navarro⁴  Antonia Serrano⁴  Juan Suarez⁴  Javier Pavón⁴  Rubén Tovar⁴  Juan Decara⁴ 

[1]Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Málaga, 29010 Málaga, Spain

[2]Departamento de Reproducción Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, 28040 Madrid, Spain

[3]Euronutra S.L. Calle Johannes Kepler, 3, 29590 Málaga, Spain

[4]Laboratorio de Medicina Regenerativa, Instituto IBIMA de Málaga, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain

关键词: AKT;    D-Pinitol;    ghrelin;    insulin;    insulin resistance;    liver;   

DOI  :  10.3390/nu12072030

来源: DOAJ

【 摘 要 】

To characterize the metabolic actions of D-Pinitol, a dietary inositol, in male Wistar rats, we analyzed its oral pharmacokinetics and its effects on (a) the secretion of hormones regulating metabolism (insulin, glucagon, IGF-1, ghrelin, leptin and adiponectin), (b) insulin signaling in the liver and (c) the expression of glycolytic and neoglucogenesis enzymes. Oral D-Pinitol administration (100 or 500 mg/Kg) resulted in its rapid absorption and distribution to plasma and liver compartments. Its administration reduced insulinemia and HOMA-IR, while maintaining glycaemia thanks to increased glucagon activity. In the liver, D-Pinitol reduced the key glycolytic enzyme pyruvate kinase and decreased the phosphorylation of the enzymes AKT and GSK-3. These observations were associated with an increase in ghrelin concentrations, a known inhibitor of insulin secretion. The profile of D-Pinitol suggests its potential use as a pancreatic protector decreasing insulin secretion through ghrelin upregulation, while sustaining glycaemia through the liver-based mechanisms of glycolysis control.

【 授权许可】

Unknown