期刊论文详细信息
Brain Sciences
Advances in Brain Tumor Surgery for Glioblastoma in Adults
Carla Vazquez-Ramos1  Deependra Mahato1  Rawan Al-Kharboosh1  Stephanie Jeanneret1  Alfredo Quinones-Hinojosa1  Montserrat Lara-Velazquez1  Gazanfar Rahmathulla2  Daryoush Tavanaiepour2 
[1] Department of Neurosurgery, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA;Department of Neurosurgery, University of Florida College of Medicine, 653 8th St W., Jacksonville, FL 32209, USA;
关键词: brain tumor surgery;    laser therapy;    awake craniotomy;    novel treatments for glioma;    optical coherence tomography;   
DOI  :  10.3390/brainsci7120166
来源: DOAJ
【 摘 要 】

Glioblastoma (GBM) is the most common primary intracranial neoplasia, and is characterized by its extremely poor prognosis. Despite maximum surgery, chemotherapy, and radiation, the histological heterogeneity of GBM makes total eradication impossible, due to residual cancer cells invading the parenchyma, which is not otherwise seen in radiographic images. Even with gross total resection, the heterogeneity and the dormant nature of brain tumor initiating cells allow for therapeutic evasion, contributing to its recurrence and malignant progression, and severely impacting survival. Visual delimitation of the tumor’s margins with common surgical techniques is a challenge faced by many surgeons. In an attempt to achieve optimal safe resection, advances in approaches allowing intraoperative analysis of cancer and non-cancer tissue have been developed and applied in humans resulting in improved outcomes. In addition, functional paradigms based on stimulation techniques to map the brain’s electrical activity have optimized glioma resection in eloquent areas such as the Broca’s, Wernike’s and perirolandic areas. In this review, we will elaborate on the current standard therapy for newly diagnosed and recurrent glioblastoma with a focus on surgical approaches. We will describe current technologies used for glioma resection, such as awake craniotomy, fluorescence guided surgery, laser interstitial thermal therapy and intraoperative mass spectrometry. Additionally, we will describe a newly developed tool that has shown promising results in preclinical experiments for brain cancer: optical coherence tomography.

【 授权许可】

Unknown   

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