Evaluation of the efficacy of Acalypha wilkesiana leaves in managing cardiovascular disease risk factors in rabbits exposed to salt-loaded diets

Clinical Phytoscience

Kingsley Omage¹  Sylvia O. Omage²  Marshall A. Azeke³ 

[1] Department of Biochemistry, College of Basic Medical Sciences, Igbinedion University;Department of Biochemistry, Faculty of Life Sciences, University of Benin;Department of Biochemistry, Faculty of Natural Sciences, Ambrose Alli University;

关键词: Acalypha wilkesiana;    Salt loaded diet;    Ethanol extract;    Aqueous extract;    Cholesterol;   

DOI  :  10.1186/s40816-018-0060-4

来源: DOAJ

【 摘 要 】

Abstract Background This study was conducted to evaluate the therapeutic benefits of oral administration of extracts of Acalypha wilkesiana leaves on some serum parameters that are indicators or risk factors of cardiovascular diseases, in salt loaded rabbits. Method Thirty experimental rabbits used for this study were randomized into five groups (A to E) of six rabbits. Rabbits in groups A to D were given salt loaded diets. Groups B and C animals were also treated with aqueous and ethanol extracts of Acalypha wilkesiana leaves respectively while rabbits in group E served as control. Results Salt loading resulted in a significantly (P < 0.05) higher serum albumin, cholesterol, LDL-cholesterol and lower serum globulin, HDL-cholesterol, triglycerides, as compared with the control. Treatment with Acalypha wilkesiana leaf extracts (aqueous or ethanol), at a dose of 300 mg/kg body weight, resulted in a significantly (P < 0.05) higher serum triglycerides, HDL-cholesterol, globulin, and lower serum total protein, albumin, LDL-cholesterol, cholesterol, as compared with the control, in the salt loaded rabbits. Conclusion Acalypha wilkesiana may be useful in the management of risk factors of cardiovascular diseases.

【 授权许可】

Unknown