UV Light Assisted Coating Method of Polyphenol Caffeic Acid and Mediated Immobilization of Metallic Silver Particles for Antibacterial Implant Surface Modification

Polymers

ChanHee Park¹  CheolSang Kim¹  LudwigErik Aguilar¹  JiYeon Lee² 

[1] Department of Bionanosystem Engineering, Chonbuk National University, Jeonju 54896, Korea;Department of Mechanical Design Engineering, Graduate School, Chonbuk National University, Jeonju 54896, Korea;

关键词: titanium implants;    polycaffeic acid;    metallic silver particles;    anti-bacterial properties;   

DOI  :  10.3390/polym11071200

来源: DOAJ

【 摘 要 】

Titanium implants are extensively used in biomedical applications due to their excellent biocompatibility, corrosion resistance, and superb mechanical stability. In this work, we present the use of polycaffeic acid (PCA) to immobilize metallic silver on the surface of titanium materials to prevent implant bacterial infection. Caffeic acid is a plant-derived phenolic compound, rich in catechol moieties and it can form functional coatings using alkaline buffers and with UV irradiation. This combination can trigger oxidative polymerization and deposition on the surface of metallic substrates. Using PCA can also give advantages in bone implants in decreasing inflammation by decelerating macrophage and osteoclast activity. Here, chemical and physical properties were investigated using FE-SEM, EDS, XPS, AFM, and contact angle. The in vitro biocompatibility and antibacterial studies show that PCA with metallic silver can inhibit bacterial growth, and proliferation of MC-3T3 cells was observed. Therefore, our results suggest that the introduced approach can be considered as a potential method for functional implant coating application in the orthopedic field.

【 授权许可】

Unknown