Human pluripotent stem cells in contemporary medicine

Issledovaniâ i Praktika v Medicine

S. A. Rodin¹ 

[1] Division of Matrix Biology Department of Medical Biochemistry and Biophysics Karolinska Institutet, StockholmScheelesvag 2, Plan 4:B1, 17177 Stockholm;

关键词: human pluripotent stem cells, human embryonic stem cells, human induced pluripotent stem cells, clinical trials involving human pluripotent stem cells;   

DOI  :  10.17709/2409-2231-2015-2-2-44-52

来源: DOAJ

【 摘 要 】

Human pluripotent stem cells (hPSCs) are capable of indefinite proliferation and can be differentiated into any cell type of the human body. Therefore, they are a promising source of cells for treatment of numerous degenerative diseases and injuries. Pluripotent stem cells are also associated with a number of ethical, safety and technological issues. In this review, we describe various types of hPSCs, safety issues that concern all or some types of hPSCs and methods of clinical-grade hPSC line development. Also, we discuss current and past clinical trials involving hPSCs, their outcomes and future perspectives of hPSC-based therapy.

【 授权许可】

Unknown