Influence of Radiation Sterilization on Properties of Biodegradable Lactide/Glycolide/Trimethylene Carbonate and Lactide/Glycolide/ε-caprolactone Porous Scaffolds with Shape Memory Behavior

Materials

Anna Smola-Dmochowska¹  Henryk Janeczek¹  Elżbieta Pamuła²  Piotr Rychter³  Piotr Dobrzyński³  Natalia Śmigiel-Gac³  Wojciech Prochwicz³ 

[1] Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Curie-Sklodowska 34 St., Zabrze 41-800, Poland;Department of Biomaterials, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al Mickiewicza 30, Kraków 30-059, Poland;Faculty of Mathematics and Natural Sciences, Jan Dlugosz University in Czestochowa, Armii Krajowej 13/15 Av., Czestochowa 42-218, Poland;

关键词: biodegradable polymer;    gamma sterilization;    electron beam sterilization;    radiation degradation;    scaffold;    shape memory;   

DOI  :  10.3390/ma9010064

来源: DOAJ

【 摘 要 】

The aim of the study was the evaluation of gamma irradiation and electron beams for sterilization of porous scaffolds with shape memory behavior obtained from biodegradable terpolymers: poly(l-lactide-co-glycolide-co-trimethylene carbonate) and poly(l-lactide-co-glycolide-co-ɛ-caprolactone). The impact of mentioned sterilization techniques on the structure of the scaffolds before and after the sterilization process using irradiation doses ranged from 10 to 25 kGy has been investigated. Treatment of the samples with gamma irradiation at 15 kGy dose resulted in considerable drop in glass transition temperature (Tg) and number average molecular weight (Mn). For comparison, after irradiation of the samples using an electron beam with the same dose, no significant changes in structure or properties of examined scaffolds have been noticed. Higher doses of irradiation via electron beam caused essential changes of the scaffolds’ pores resulting in partial melting of their surface. Nevertheless, obtained results have revealed that sterilization with electron beam, when compared to gamma irradiation, is a better method because it does not affect significantly the physicochemical properties of the scaffolds. Both used methods of sterilization did not influence the shape memory behavior of the examined materials.

【 授权许可】

Unknown