Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection

Nutrients

Yang-Chang Wu¹  Chien-Yi Ho²  Chih-Yen Tu³  Fang-Ju Cheng⁴  Yeh Chen⁴  Wei-Chien Huang⁴  Yi-Cheng Shen⁵  Chih-Hsin Tang⁵  Thanh-Kieu Huynh⁵  Dai-Wei Hu⁵  Chia-Shin Yang⁶ 

[1] Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan;Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 404, Taiwan;Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung 404, Taiwan;Drug Development Center, China Medical University, Taichung 404, Taiwan;Graduate Institute of Biomedical Science, China Medical University, Taichung 404, Taiwan;Institute of New Drug Development, China Medical University, Taichung 404, Taiwan;

关键词: hesperidin;    TMPRSS2;    ACE2;    SARS-CoV-2;    D614G;    501Y.v2;   

DOI  :  10.3390/nu13082800

来源: DOAJ

【 摘 要 】

Hesperidin (HD) is a common flavanone glycoside isolated from citrus fruits and possesses great potential for cardiovascular protection. Hesperetin (HT) is an aglycone metabolite of HD with high bioavailability. Through the docking simulation, HD and HT have shown their potential to bind to two cellular proteins: transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2), which are required for the cellular entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our results further found that HT and HD suppressed the infection of VeroE6 cells using lentiviral-based pseudo-particles with wild types and variants of SARS-CoV-2 with spike (S) proteins, by blocking the interaction between the S protein and cellular receptor ACE2 and reducing ACE2 and TMPRSS2 expression. In summary, hesperidin is a potential TMPRSS2 inhibitor for the reduction of the SARS-CoV-2 infection.

【 授权许可】

Unknown