The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections

Antibiotics

Francesca Ghirga¹  Bruno Casciaro¹  Cristina Del Plato²  Bruno Botta²  Silvia Cammarone²  Deborah Quaglio²  Maria Luisa Mangoni³  Floriana Cappiello³  Maria Rosa Loffredo³ 

[1] Center For Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy;Department of Chemistry and Technology of Drugs, “Department of Excellence 2018−2022”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy;Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy;

关键词: antibiotic resistance;    plant secondary metabolites;    plant-derived natural products;    terpenes;    diterpenes;    triterpenes;   

DOI  :  10.3390/antibiotics9060325

来源: DOAJ

【 摘 要 】

The discovery of antibiotics has revolutionized the medicine and treatment of microbial infections. However, the current scenario has highlighted the difficulties in marketing new antibiotics and an exponential increase in the appearance of resistant strains. On the other hand, research in the field of drug-discovery has revaluated the potential of natural products as a unique source for new biologically active molecules and scaffolds for the medicinal chemistry. In this review, we first contextualized the worldwide problem of antibiotic resistance and the importance that natural products of plant origin acquire as a source of new lead compounds. We then focused on terpenes and their potential development as antimicrobials, highlighting those studies that showed an activity against conventional antibiotic-resistant strains.

【 授权许可】

Unknown