What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders?

International Journal of Molecular Sciences

RobertP. Friedland¹  JosephD. McMillan²  Zimple Kurlawala³ 

[1] Department of Neurology, University of Louisville School of Medicine, Louisville, KY 40202, USA;Department, University of South Florida, Tampa, FL 33620, USA;National Institute on Aging, Bethesda, MD 33620, USA;

关键词: alzheimer’s disease;    microbiota;    bacterial amyloid;    fuba;    curli;    csga;    amyloid beta;    neuroinflammation;   

DOI  :  10.3390/ijms21051652

来源: DOAJ

【 摘 要 】

Despite the enormous literature documenting the importance of amyloid beta (Ab) protein in Alzheimer's disease, we do not know how Ab aggregation is initiated and why it has its unique distribution in the brain. In vivo and in vitro evidence has been developed to suggest that functional microbial amyloid proteins produced in the gut may cross-seed Ab aggregation and prime the innate immune system to have an enhanced and pathogenic response to neuronal amyloids. In this commentary, we summarize the molecular mechanisms by which the microbiota may initiate and sustain the pathogenic processes of neurodegeneration in aging.

【 授权许可】

Unknown