Effect of gastric acid resistant coating of fish oil capsules on intestinal uptake of eicosapentaenoic acid and docosahexaenoic acid

Journal of Functional Foods

Henrike Meyer¹  Jan Philipp Schuchardt²  Inga Schneider³  Andreas Hahn⁴ 

[1] Institute of Food Science and Human Nutrition, Leibniz University Hannover, Am Kleinen Felde 30, 30167 Hannover, Germany;fax: [phone].;Corresponding author: Tel.: [phone];Institute of Food Science and Human Nutrition, Leibniz University Hannover, Am Kleinen Felde 30, 30167 Hannover, Germany;

关键词: Omega-3 fatty acids;    Bioavailability;    Absorption;    Enteric coating;    EPA;    DHA;   

DOI  :  

来源: DOAJ

【 摘 要 】

Fish oil capsules with gastric acid resistant coatings have been shown to lower undesirable side effects. We compared the eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) uptake from uncoated and coated fish oil capsules. In a double-blinded crossover trial 12 healthy young men (mean age 31 years) were randomized to 1680 mg EPA + DHA as triacylglycerols in uncoated or coated fish oil capsules. Fatty acid levels were analyzed in plasma phospholipids at baseline and 2, 4, 6, 8, 24, 48 and 72 h after capsule ingestion. Statistical group comparisons on the basis of area under the curve values revealed no significant differences for EPA, DHA and total n-3 fatty acid levels between the different capsule formulations. In conclusion, this nutrikinetic study indicates that coating of fish oil capsules with a gastric acid resistant layer has no influence on the bioavailability of EPA + DHA.

【 授权许可】

Unknown