Effects of Baru Almond Oil (Dipteryx alata Vog.) Treatment on Thrombotic Processes, Platelet Aggregation, and Vascular Function in Aorta Arteries

Nutrients

Lorena Soares Bezerra¹  José Luiz de Brito Alves¹  Cristiane Cosmo Silva-Luis¹  Júlio César Pinheiro Lúcio de Oliveira²  Islania Giselia Albuquerque Araújo²  Isac Almeida de Medeiros²  Marianna Vieira Sobral²  Yuri Mangueira do Nascimento²  Fátima de Lourdes Assunção Araújo de Azevedo²  Robson Cavalcante Veras²  Vivianne Mendes Mangueira²  Josean Fechine Tavares²  José Alixandre de Sousa Luis² 

[1] Health Sciences Center, Department of Nutrition, Campus I, Federal University of Paraíba, João Pessoa 58059-900, PB, Brazil;Health Sciences Center, Department of Pharmaceutical Sciences, Campus I, Federal University of Paraíba, João Pessoa 58059-900, PB, Brazil;

关键词: Dipteryx alata Vog.;    Fabaceae;    tocopherols;    thrombosis;    platelet aggregation;    vascular response;   

DOI  :  10.3390/nu14102098

来源: DOAJ

【 摘 要 】

Background: This study assessed the effects of Baru (Dipteryx alata Vog.) almond oil supplementation on vascular function, platelet aggregation, and thrombus formation in aorta arteries of Wistar rats. Methods: Male Wistar rats were allocated into three groups. The control group (n = 6), a Baru group receiving Baru almond oil at 7.2 mL/kg/day (BG 7.2 mL/kg, n = 6), and (iii) a Baru group receiving Baru almond oil at 14.4 mL/kg/day (BG 14.4 mL/kg, n = 6). Baru oil was administered for ten days. Platelet aggregation, thrombus formation, vascular function, and reactive oxygen species production were evaluated at the end of treatment. Results: Baru oil supplementation reduced platelet aggregation (p < 0.05) and the production of the superoxide anion radical in platelets (p < 0.05). Additionally, Baru oil supplementation exerted an antithrombotic effect (p < 0.05) and improved the vascular function of aorta arteries (p < 0.05). Conclusion: The findings showed that Baru oil reduced platelet aggregation, reactive oxygen species production, and improved vascular function, suggesting it to be a functional oil with great potential to act as a novel product for preventing and treating cardiovascular disease.

【 授权许可】

Unknown