Microfluidic Quantification of Blood Pressure and Compliance Properties Using Velocity Fields under Periodic On–Off Blood Flows

Applied Sciences

YangJun Kang¹ 

[1] Department of Mechanical Engineering, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Korea;

关键词: blood pressure;    equivalent compliance;    microfluidic-based compliance unit;    time constant;    blood velocity fields;    regression analysis;   

DOI  :  10.3390/app10155273

来源: DOAJ

【 摘 要 】

To monitor variations of blood samples effectively, it is required to quantify static and dynamic properties simultaneously. With previous approaches, the viscosity and elasticity of blood samples are obtained for static and transient flows with two syringe pumps. In this study, simultaneous measurement of pressure and equivalent compliance is suggested by analyzing the velocity fields of blood flows, where a blood sample is delivered in a periodic on-off fashion with a single syringe pump. The microfluidic device is composed of a main channel (mc) for quantifying the equivalent compliance and a pressure channel (pc) for measuring the blood pressure. Based on the mathematical relation, blood pressure at junction (P_x) is expressed as P_x = kβ. Here, β is calculated by integrating the averaged velocity in the pressure channel (pc>). The equivalent compliance (C_eq) is then quantified as C_eq = λ_off · Q₀/P_x with a discrete fluidic model. The time constant (λ_off ) is obtained from the transient behavior of the averaged blood velocity in the main channel (<U_mc>). According to results, P_x and C_eq varied considerably with respect to the hematocrit and flow rate. The present method (i.e., blood pressure, compliance) shows a strong correlation with the previous method (i.e., blood viscosity, elasticity). In conclusion, the present method can be considered as a potential tool for monitoring the mechanical properties of blood samples supplied periodically from a single syringe pump.

【 授权许可】

Unknown