Analysis of misdiagnosed cases of hemorrhagic fever with renal syndrome in children: two cases and literature review

BMC Nephrology

Bai-chao Sun¹  Qing-shan Ma¹  Yan Zhang¹  Leng-yue Zhao¹  Li Zhang¹ 

[1] Department of Pediatrics Nephrology, First Hospital, Jilin University;

关键词: Hemorrhagic fever with renal syndrome;    Children;    Atypical;    Hantavirus;   

DOI  :  10.1186/s12882-019-1562-0

来源: DOAJ

【 摘 要 】

Abstract Background Hemorrhagic fever with renal syndrome (HFRS) is an acute disease caused by hantavirus infection and is clinically characterized by fever, various hemorrhagic manifestations and transient renal and hepatic dysfunctions. Although various cases of HFRS have been reported, cases in children have rarely been described. Herein, we report two atypical cases of HFRS in children without distinctive manifestations and typical disease clinically progresses. Case presentation Patient 1 was a 11-year-old girl who attended our clinic for fever accompanying with acute renal failure, proteinuria and decreased level of complement 3 (C3) and thrombocytopenia without any hemorrhagic manifestations, acute glomerulonephritis was suspected first, especially lupus nephritis. Patient 2 was misdiagnosed as encephalitis at local hospital because of fever and headache for 4 days. With elevated liver transaminases, proteinuria and normal cerebrospinal fluid examination, HFRS was taken into consideration. Both of the two cases were supported and confirmed by serological test for Hantavirus. Conclusions Clinical manifestations of HFRS in children often presented atypically and were milder than adults. Febrile disease accompanying with thrombocytopenia may lead to the suspected diagnosis of HFRS.

【 授权许可】

Unknown