Prolactin increases cell migration of MCF-7 cells without inducing an epithelium-mesenchyme transition

Gaceta Mexicana de Oncología

Deissy Herrera-Covarrubias¹  Jorge M. Suárez-Medellín¹  Gonzalo E. Aranda-Abreu¹  Ma. Elena Hernández-Aguilar¹  Fausto Rojas-Durán¹  Jesús A. Lara-Reyes²  Zuleima H. Castillo-García³  Arnoldo Aquino-Gálvez⁴  Clara L. Sampieri-Ramírez⁵ 

[1] Brain Research Institute, Universidad Veracruzana, Xalapa, Ver., Mexico;Brain Research, Universidad Veracruzana, Xalapa, Ver., Mexico;Faculty of Bioanalysis, Universidad Veracruzana, Xalapa, Ver., Mexico;Molecular Biology Laboratory, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico;Public Health Institute, Universidad Veracruzana, Xalapa, Ver., Mexico;

关键词: Prolactin. MCF-7 cells. Epithelial-mesenchymal transition. Cell migration assays. Cell movement. Breast neoplasms.;   

DOI  :  10.24875/j.gamo.22000006

来源: DOAJ

【 摘 要 】

Objective: To evaluate the effect of prolactin (PRL) on the migration of MCF-7 breast cancer cells and the expression of E-cadherin. Methods: We used the wound healing assays to evaluate the migration of MCF-7 cells and the Western blot technique to evaluate the expression of E-cadherin. Results: The results show that PRL produced an increase in the migration of MCF-7 cells without inducing a reduction in the expression of E-cadherin. Conclusions: Prolactin significantly increased the migration of MCF-7 breast cancer cell line without inducing an epithelial-mesenchymal transition (EMT), which could be related to a collective type of migration.

【 授权许可】

Unknown