Synthesis and characterization of critical process related impurities of an asthma drug – Zafirlukast

Journal of Saudi Chemical Society

Vurimidi Himabindu¹  Ghanta Mahesh Reddy²  Anumula Raghupathi Reddy³  Gilla Goverdhan³ 

[1] Institute of Science and Technology, Center for Environmental Science, J.N.T. University, Kukatpally, Hyderabad 500 072, Andhra Pradesh, India;Macleods Pharmaceuticals Ltd., Shanti Nagar, Andheri East, Mumbai 400059, Maharashtra, India;Research and Development, Dr. Reddy’s Laboratories Ltd., Integrated Product Development, Survey Nos. 42, 45, 46, and 54, Bachupally, Qutubullapur, Ranga Reddy District 500 072, Andhra Pradesh, India;

关键词: Zafirlukast;    Asthma drug;    Process impurities;    Leukotriene;   

DOI  :  10.1016/j.jscs.2011.06.002

来源: DOAJ

【 摘 要 】

Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the treatment of pulmonary disorders such as asthma. During the process development of zafirlukast, eight process related impurities were observed at a level of 0.1–0.15 area percent. Synthesis and characterization of these impurities and investigation of the root cause of their formation is described.

【 授权许可】

Unknown