The Intricate Role of Growth Hormone in Metabolism

Frontiers in Endocrinology

Archana eVijayakumar¹  Shoshana eYakar¹  Derek eLeroith¹ 

[1] Mt Sinai School of Medicine;

关键词: Carbohydrates;    Growth Hormone;    Insulin Resistance;    Lipids;    Metabolism;    tissue-specific;   

DOI  :  10.3389/fendo.2011.00032

来源: DOAJ

【 摘 要 】

Growth hormone (GH), a master regulator of somatic growth, also regulates carbohydrate and lipid metabolism via complex interactions with insulin and insulin-like growth factor-1 (IGF-1). Data from human and rodent studies reveal the importance of GH in insulin synthesis and secretion, lipid metabolism and body fat remodeling. In this review, we will summarize the tissue-specific metabolic effects of GH, with emphasis on recent targets identified to mediate these effects. Furthermore, we will discuss what role GH plays in obesity and present possible mechanisms by which this may occur.

【 授权许可】

Unknown