Side Effects of Brolucizumab

Journal of Ophthalmic & Vision Research

William R.Freeman¹  Fatemeh Abdi²  Saeed Mohammadi³  Tahmineh Motevasseli⁴ 

[1] Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA;Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran;Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran;Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: anti-vascular endothelial growth factor;    brolucizumab;    wet age-related macular degeneration;   

DOI  :  10.18502/jovr.v16i4.9757

来源: DOAJ

【 摘 要 】

Abstract Age-related macular degeneration and its complication, subretinal neovascularization, are common causes of progressive, irreversible impairment of central vision. Anti-vascular endothelial growth factor (anti-VEGF) therapy has improved the visual outcome and provided an evolution in the treatment of retinal disease. The current four anti-VEGF drugs – pegaptanib, ranibizumab, aflibercept, and bevacizumab – have been administered for many years. A new anti-VEGF agent, brolucizumab, was approved by the U.S. Food and Drug Administration (FDA) in late 2019 for the treatment of wet age-related macular degeneration. Brolucizumab is a novel single-chain fragment variable antibody that inhibits all isoforms of VEGF-A and has been suggested to have more tissue penetration. Despite all the benefits, there are some reports of serious side effects that need to be understood in managing patients. Brolucizumab has been reported to cause occlusive retinal vasculitis in the setting of intraocular inflammation, which has not been seen in other anti-VEGF medications. A PubMed and Scopus search was performed and all article types were included. In the present article, we have reviewed the reported side effects of brolucizumab.

【 授权许可】

Unknown